CEDAR Webinar #3 "Diagnosis and Referral of Retinoblastoma", Friday 18 November 2022 from 2 - 3 pm UTC

 

SIOP Childhood Cancer Early Diagnosis & Appropriate Referral (CEDAR) Project

 

Dr. Rashmi Dalvi and Dr. Maya Prasad (Members, SIOP Education and Training Committee)

On behalf of the SIOP Education and Training Committee and IPA SAG on NCD

The SIOP CEDAR Project is improving the knowledge and understanding of healthcare providers who are involved in the initial care, diagnostic workup, and referral of pediatric patients suspected of having cancer.

The third CEDAR webinar, “Diagnosis and referral of Retinoblastoma” is taking place on 18 November. SIOP and IPA encourage Pediatricians, Ophthalmologists, Family Practitioners, Community Nurses, and other healthcare professionals who are involved in the care of children with cancer to register for this webinar.

What is Retinoblastoma?

Retinoblastoma is a disease of early childhood with 80% of cases occurring under 4 years of age. Affected children may present as young as early infancy, and the disease may be either unilateral or bilateral. About two third of retinoblastoma cases have non-hereditary sporadic presentations while 30-40% are inherited. Though seen globally, research suggests a higher incidence of retinoblastoma in Central and South America, Middle East Asia, and Indian Subcontinent. The commonest early manifestations are the white-eye reflex (leukocoria), followed by strabismus/squint, which could be identified on a routine physical examination (including at well-baby visits).

 

Diagnosis of Retinoblastoma

Since retinoblastoma in its early stages presents with signs and symptoms only related to the eye, and the child may appear otherwise healthy, the diagnosis may be delayed or missed. This often leads to advanced intraocular presentation and extra-ocular disease. Timely and early diagnosis is possible by diligent examination of the eyes in infants and young children.

The benefit of screening and early diagnosis in pediatric cancers is best demonstrated in retinoblastoma. Retinoblastoma is highly curable when detected and treated early – the disease-free survival at 5 years is 80-90% for intraocular tumors, contrary to 30-40 % survival outcomes for advanced disease. Preservation of vision and avoidance of eyeball enucleation may be possible if retinoblastoma is detected at an early stage. Prompt referral to centers with multidisciplinary expertise is important to help ensure appropriate treatment and enable the best possible care.

Treatment of Retinoblastoma

The treatment of retinoblastoma is individualized based on intraocular extent and staging and includes conventional chemotherapy, focal therapies, surgery, newer modalities, and rarely, radiation therapy. Less therapy is needed in earlier stages. Children with retinoblastoma need genetic counseling and screening, particularly in early-onset/bilateral and familial cases. Surveillance for recurrence is needed until 5-7 years of age.

 

SIOP CEDAR PROJECT:

The International Society of Pediatric Oncology (SIOP) has launched “Childhood Cancer Early Diagnosis and Appropriate Referral” (CEDAR) project in collaboration with the International Pediatric Association (IPA). In the first phase of the CEDAR project, SIOP and IPA are organizing a series of monthly webinars (started in September 2022) to highlight the importance of early diagnosis, with a focus on the six WHO index cancers (acute lymphoblastic leukemia, Hodgkin lymphoma, Burkitt’s lymphoma, Wilms tumor, retinoblastoma, and low-grade glioma). Each CEDAR webinar is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) with 1 credit point. These webinars are free to attend and open to everyone, and we are offering simultaneous Spanish translation.

Recordings of the first two webinars are available on the following links:

1.      Webinar 1: Outcomes of childhood cancers: Gaps and Disparities to be addressed

https://www.youtube.com/watch?v=3d2U0sajKr4

 

2.      Diagnosis and Referral of Acute Leukemia

https://youtu.be/VBp8nbRlRDQ

 

CEDAR WEBINAR – Diagnosis and referral of Retinoblastoma:

The third CEDAR webinar is scheduled for 18th November 2022 at 2-3 PM UTC/GMT on “Diagnosis and referral of Retinoblastoma”. This webinar will be co-moderated by Dr. Erin Peckham-Gregory, SIOP Education and Training Committee (USA), Dr. Julia Challinor, Secretary General SIOP (USA), and Dr. Feyza Darendeliler, IPA (Turkey). The agenda of this educational session is as follows:

1.      Retinoblastoma case presentation: Dr. Alexander Lloyd Ng (Philippines)

2.      When to suspect retinoblastoma?: Dr. Clarissa Matosinho (Brazil)

3.      Approach for diagnosis, initial management, and referral: Dr. Swathi Kaliki (India)

4.      Panel Discussion with Expert Panelists

·        Dr. Guillermo Chantada, President SIOP (Uruguay)

·        Dr. Rejin Kebudi, Secretary General Elect SIOP (Turkey)

·        Dr. Francois Doz (France)

·        Dr. Sandra Staffieri (Australia)

 

Link for registration: https://us06web.zoom.us/webinar/register/WN_4-7IJRMDRVatv4u8gS-bKQ

 

FUTURE CEDAR WEBINARS:

Please save the dates and register for our future CEDAR webinars:

Webinar 4:  16th December 2022	Diagnosis and Referral of Low-Grade Glioma (Brain Tumors)	https://us06web.zoom.us/webinar/register/WN_bndRVY7PR_KgZ6ayPLay0g
Webinar 5: 20th January 2023	Diagnosis and Referral of Hodgkin Lymphoma	https://us06web.zoom.us/webinar/register/WN_xz0g18W-QCC6Xt3BpMA7Ig
Webinar 6: 3rd February 2023	Diagnosis and Referral of Burkitt’s Lymphoma	https://us06web.zoom.us/webinar/register/WN_OPV3UWKQT5-T0DFjNxD7FA
Webinar 7: 10th March 2023	Diagnosis and Referral of Wilms Tumor	https://us06web.zoom.us/webinar/register/WN_koxfsR-fR26pUcH1vIvWLw

For queries or further information, please visit siop-online.org/cedar or email info@siop-online.org

 

Rashmi Dalvi (MD) is a pediatric hematologist-oncologist from India. An active member of the SIOP Education and Training Committee and the SIOP CEDAR project, she also helped develop and led the pediatric oncology for pediatricians project in India since 1997.  She is a past President of SIOP Asia and presently serves on the Executive Council of the Asian Pediatric Hematology Oncology Group (APHOG.)

Maya Prasad (MD) is Professor of Paediatric Oncology at Tata Memorial Centre, Mumbai. She has been serving as co-chair of the SIOP Nutrition Network and an active member of the SIOP Education and Training Committee. She has special interests in Paediatric Solid Tumors including retinoblastoma, Supportive Care in Paediatric Oncology, and Late Effects in Survivors of Childhood Cancer.

 

 

SIOP

The International Society of Paediatric Oncology (SIOP) is the only global multidisciplinary society entirely devoted to pediatric and adolescent cancer. SIOP, as a non-state actor in official relations with WHO, is committed to contribute substantially to WHO Global Initiative for Childhood Cancer. We have over 2,600 members worldwide including doctors, nurses, other healthcare professionals, scientists, and researchers.

Visit siop-online.org for more information.

 

IPA

The International Pediatric Association (IPA) exists to create a world where all children, regardless of age, location, or family situation can live healthy lives. IPA advocates globally, nationally, and locally for high-quality, evidence-based, and child-centered pediatric care. We are a respected partner of WHO and UNICEF and provide global leadership on emerging child health issues through our work with leading global health players.

Visit ipa-world.org for more information.